Table 4.

Metabolic pathway analysis in HMVP-2 cells

	Hits	Impact	CUR	RES	UA	CUR + RES	CUR + US	UA + RES
Alanine, aspartate and glutamate metabolism	10/24	0.76	0.190	0.815	0.110	0.051	0.001	0.017
Arginine and proline metabolism	14/44	0.54	0.073	0.399	0.002	0.035	0.001	0.007
Ascorbate and aldarate metabolism	2/9	0.40	0.190	0.399	0.216	0.007	0.003	0.037
Citrate cycle (TCA cycle)	6/20	0.33	0.421	0.605	0.161	0.202	0.008	0.031
D-Glutamine and D-glutamate metabolism	3/5	1.00	0.274	0.611	0.155	0.035	0.002	0.029
Glutathione metabolism	6/26	0.45	0.073	0.380	0.099	0.035	0.022	0.110
Glycine, serine and threonine metabolism	8/31	0.60	0.147	0.481	0.009	0.110	0.001	0.007
Glyoxylate and dicarboxylate metabolism	3/18	0.39	0.333	0.605	0.161	0.151	0.030	0.049
Histidine metabolism	7/15	0.52	0.179	0.605	0.017	0.024	0.003	0.015
Methane metabolism	2/9	0.40	0.469	0.380	0.013	0.110	0.035	0.017
Nicotinate and nicotinamide metabolism	2/13	0.21	0.190	0.126	0.408	0.035	0.008	0.079
Phenylalanine metabolism	4/11	0.54	0.277	0.493	0.027	0.051	0.021	0.626
Phenylalanine, tyrosine and tryptophan biosynthesis	2/4	1.00	0.190	0.399	0.003	0.043	0.016	0.439
Pyrimidine metabolism	11/41	0.27	0.077	0.481	0.018	0.032	0.010	0.010
Taurine and hypotaurine metabolism	1/8	0.43	0.244	0.704	0.001	0.100	0.000	0.005
Valine, leucine and isoleucine biosynthesis	4/11	1.00	0.081	0.611	0.000	0.004	0.002	0.001

Metabolic pathway analysis was performed on the identified polar metabolites. Pathways with impact greater than 0.2 are included. The column “Hits” includes the number of identified compounds over the total number of compounds in the specific pathway