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. 2017 Nov 28;12(11):e0188277. doi: 10.1371/journal.pone.0188277

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© 2017 Nurrohman et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 8 — TEM images of the samples after demineralization (A; DE), demineralization in the presence of PI (B; DEpi), demineralization followed by remineralization (C; DE-REM), demineralization followed by remineralization in the presence of PI (D; DE-REMpi), and demineralization in the presence of PI followed by remineralization in the presence of PI (E; DEpi-REMpi). Before PILP-treatment showing the collagenous matrix at the acid-etch outer lesion sites (open arrowhead) was severely demineralized but contained sparsely arranged crystallites (pointers). In the DEpi group, the effect of demineralization decreases and the outer lesion sites had a higher electron density (asterisk) compared with that of the DE group. After PILP-treatment, regardless in the presence or absence of PI, showing electron-dense intrafibrillar and/or extrafibrillar apatite crystals, which were deposited within collagen scaffold. E = Epoxy resin.