Fig 7. Structure-based sequence alignment of VP8*s.

The VP8* sequences of P[19] and other P[II] (P[4], P[6] and P[8]) and two P[I] RVs (P[10] and P[12]) are included and the amino acids corresponding to the binding site of P[19] VP8* are highlighted in purple. The VP8* sequences of other RVs with known binding sites are also included. The amino acids of their binding sites are highlighted in red for P[3] and P[7] that recognize the sialic acids and P[14] that recognizes the A-HBGAs. The amino acids of the binding site of P[11] RVs are highlighted in green that recognizes the poly-linker type 2 HBGA precursors.