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General scheme of chemoenzymatic synthesis of glycoengineered IgGs and gsADCs. EndoS, endo-β-N-acetylglucosaminidase from Streptococcus pyogenes; Fuc, fucose; Gal, galactose; GlcNAc, N-acetylglucosamine; KVANKT, Lys-Val-Ala-Asn-Lys-Thr; Man, mannose; NeuAc, N-acetylneuraminic acid.
