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. Author manuscript; available in PMC: 2018 Sep 20.
Published in final edited form as: ACS Chem Neurosci. 2017 Jul 12;8(9):2039–2055. doi: 10.1021/acschemneuro.7b00187

Figure 1.

Figure 1

Dihydropyrimidine-thiones protect yeast cells against Aβ toxicity. (A) Z-Scores of a small molecule screen of the BU-CMD compound collection against our yeast Aβ toxicity model. The screen was performed in duplicate (replicates A and B) with the six DHPM-thione hits indicated by red circles and numbers. Hits (1) and (4) have overlapping Z-scores. (B) Compound plates were also screened against other yeast toxicity models, including α-syn, TDP-43, and polyglutamine (72Q). Z-Scores under 3.0 for six DHPM-thione hits indicate that the series was selective for the Aβ model. (C) General structure of DHPM-thione hits with table indicating R1 and R2 group substituents.