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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Synapse. 2017 Oct 7;72(1):10.1002/syn.22012. doi: 10.1002/syn.22012

Figure 3. Locomotor sensitization to cocaine in C57BL/6J mice.

Figure 3

(A) On the test day, the GHSR1a antagonist pre-treatment reduced cocaine locomotion in both saline sensitized and cocaine sensitized groups at multiple time points (n= 6 mice/group, ANOVA: interaction P < 0.0001; treatment P< 0.0001; Tukey`s post hoc test: cocaine-sensitized group compared to saline sensitized group, #p<0.05; YIL781 compared to saline pre-treatment, *p<0.05). (B) Data showing the sum of distance traveled during 30 min after cocaine administration (ANOVA: treatment P < 0.0001; Tukey`s post hoc test: cocaine-sensitized group compared to saline sensitized group, #p<0.05, ##p<0.01; YIL781 compared to saline pre-treatment, *p<0.05, **p<0.01).