Table 1.
Clinical Characteristics of Patients Overall and by ADM Usage
| Characteristics | Overall N=1297 | ADM usage | p-Value | |
|---|---|---|---|---|
|
| ||||
| ADM used N=655 | ADM not used N=642 | |||
| Age, mean (SD) | 48.4 (10.4) | 48.8 (10.5) | 48.1 (10.2) | 0.205 |
| BMI, mean (SD) | 25.7 (5.3) | 25.7 (5.5) | 25.6 (5.1) | 0.778 |
| Months to exchange, median (range)1 | 5.5 (26.7) | 5.4 (25.7) | 5.6 (25.1) | 0.775 |
| Laterality | ||||
| Unilateral | 490 (37.8%) | 250 (38.2%) | 240 (37.4%) | 0.771 |
| Bilateral | 807 (62.2%) | 405 (61.8%) | 402 (62.6%) | |
| Indication for mastectomy | ||||
| Therapeutic | 1162 (89.6%) | 563 (86.0%) | 599 (93.3%) | 0.000 |
| Prophylactic | 135 (10.4%) | 92 (14.0%) | 43 (6.7%) | |
| Mastectomy type | ||||
| Nipple sparing | 220 (17.0%) | 143 (21.8%) | 77 (12.0%) | 0.000 |
| Simple or modified radical | 1077 (83.0%) | 512 (78.2%) | 565 (88.0%) | |
| Smoking status | ||||
| Non-smoker | 864 (67.2%) | 454 (70.1%) | 410 (64.4%) | 0.089 |
| Previous smoker | 391 (30.4%) | 181 (27.9%) | 210 (33.0%) | |
| Current smoker | 30 (2.3%) | 13 (2.0%) | 17 (2.7%) | |
| Diabetes (NIDDM and IDDM) | ||||
| Yes | 37 (2.9%) | 19 (2.9%) | 18 (2.8%) | 0.916 |
| No | 1260 (97.1%) | 636 (97.1%) | 624 (97.2%) | |
| Lymph node management | ||||
| None | 241 (18.6%) | 158 (24.1%) | 83 (12.9%) | 0.000 |
| SLNB only | 636 (49.0%) | 295 (45.0%) | 341 (53.1%) | |
| ALND with or without SLNB | 420 (32.4%) | 202 (30.8%) | 218 (34.0%) | |
| Radiation | ||||
| Before reconstruction | 61 (4.7%) | 25 (3.8%) | 36 (5.6%) | 0.024 |
| During reconstruction2 | 192 (14.8%) | 105 (16.0%) | 87 (13.6%) | |
| After reconstruction | 69 (5.3%) | 25 (3.8%) | 44 (6.9%) | |
| None | 975 (75.2%) | 500 (76.3%) | 475 (74.0%) | |
| Chemotherapy | ||||
| During or after reconstruction | 440 (33.9%) | 193 (29.5%) | 247 (38.5%) | 0.001 |
| Not during or after reconstruction | 857 (66.1%) | 462 (70.5%) | 395 (61.5%) | |
Abbreviations: ADM, acellular dermal matrix; BMI, body mass index; SLNB, sentinel lymph node biopsy; ALND, axillary lymph node dissection; SD, standard deviation.
1
Defined as the number of months between the initial placement of tissue expander and exchange for final implant; based on non-failure patients who underwent exchange.
2
Defined as radiation received after the placement of tissue expander but before the exchange for final implant.