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. Author manuscript; available in PMC: 2018 Nov 27.
Published in final edited form as: Annu Rev Genet. 2017 Aug 30;51:63–82. doi: 10.1146/annurev-genet-120116-024554

Figure 4.

Figure 4

Tissue regeneration enhancer elements (TREEs) control regeneration capacity in zebrafish. (a) After amputation injuries, a TREE linked to the leptin b gene (LEN) can rescue regeneration defects in adult fgf20a mutants (dob) when paired with an fgf20a expression cassette. (b) Conversely, the same TREE can effect a block in tailfin regeneration in the wild-type background when paired with the expression of a dominant negative Fgfr1. Intriguingly, these transgenic animals undergo normal development, whereas their regeneration capacity is modified. Thus, the LEN element appears to be specifically activated after injury and during regeneration.