Table 2.
Summary of liver BED reductions achieved by spatiotemporal fractionation. By definition, percentage reductions in BED and EQD8 are equal. The first column indicates patient number, total GTV volume, and treatment scheme (e.g. 5×3 fx indicates a 15-fraction treatment consisting of 5 distinct fractions delivered 3 times each).
| reference | spatiotemporal plan 2 | spatiotemporal plan 1 | ||||
|---|---|---|---|---|---|---|
| Patient | Structure | mean dose [Gy] | dose red. [%] | BED red. [%] | dose red. [%] | BED red. [%] |
| 1 (391 cc) | GTV | 51.8 | 9.3 | 0 | 9.5 | 0 |
| 5×1 fx | Liver-GTV | 18.3 | 18.2 | 12.8 | 14.2 | 8.4 |
| Liver-PTV | 16.2 | 19.9 | 17.3 | 15.0 | 11.7 | |
| 2 (201 cc) | GTV | 51.2 | 9.2 | 0 | 9.2 | 0 |
| 5×1 fx | Liver-GTV | 11.8 | 16.1 | 8.5 | 11.9 | 4.5 |
| Liver-PTV | 9.0 | 18.2 | 15.8 | 12.5 | 9.9 | |
| 3 (207 cc) | GTV | 51.6 | 5.8 | 0 | 5.8 | 0 |
| 5×1 fx | Liver-GTV | 18.1 | 12.0 | 6.5 | 9.4 | 3.8 |
| Liver-PTV | 13.0 | 14.7 | 12.7 | 10.7 | 8.5 | |
| 4 (228 cc) | GTV | 52.2 | 1.4 | 0 | 0.6 | 0 |
| 5×1 fx | Liver-GTV | 9.0 | 13.7 | 13.0 | 2.0 | 1.4 |
| Liver-PTV | 6.5 | 18.8 | 20.3 | 2.5 | 2.3 | |
| 5 (647 cc) | GTV | 51.8 | 8.4 | 0 | 8.2 | 0 |
| 5×1 fx | Liver-GTV | 18.0 | 18.9 | 11.7 | 12.3 | 4.5 |
| Liver-PTV | 10.5 | 29.9 | 28.6 | 16.3 | 13.9 | |
| 1 (391 cc) | GTV | 71.3 | 7.0 | 0 | 5.9 | 0 |
| 5×3 fx | Liver-GTV | 23.9 | 12.9 | 8.1 | 9.2 | 4.7 |
| Liver-PTV | 21.0 | 14.2 | 11.1 | 9.9 | 6.7 | |
| 1 (391 cc) | GTV | 79.8 | 5.4 | 0 | 5.0 | 0 |
| 5×5 fx | Liver-GTV | 26.1 | 10.4 | 6.2 | 7.8 | 3.8 |
| Liver-PTV | 22.8 | 11.5 | 8.5 | 8.4 | 5.4 | |
| 3 (391 cc) | GTV | 51.6 | 5.5 | 0 | 5.4 | 0 |
| 4+1 fx | Liver-GTV | 18.1 | 4.0 | 2.4 | 2.5 | 0.7 |
| Liver-PTV | 13.0 | 5.0 | 4.7 | 2.7 | 2.1 | |