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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: J Autoimmun. 2017 Jul 6;85:64–77. doi: 10.1016/j.jaut.2017.06.012

Figure 1. FPRs control the first wave neutrophil infiltration in Listeria infection.

Figure 1

Both Fpr1 and Fpr2 expressed by mouse neutrophils sense bacteria-derived chemotactic PAMPs to mediate a rapid neutrophil influx into the liver of listeria-infected mice. Listeria lipoproteins stimulate TLR2 on hepatocytes and leukocytes to trigger the production of CXCR2-specific chemokines to mobilize a late wave neutrophil recruitment in the liver. Neutrophils activated by bacterial FPR (Fpr) ligands produce superoxide which is critical for pathogen elimination.