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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: J Autoimmun. 2017 Jul 6;85:64–77. doi: 10.1016/j.jaut.2017.06.012

Figure 2. Sequential CCR2-Fpr2-CCR7 signals mediate DC trafficking in allergic airway inflammation.

Figure 2

The chemokine receptor CCR2 mobilizes inflammatory DC precursors from the circulation to the perivascular regions of the inflamed lung in response to the cognate ligand CCL2. Once in the perivascular regions, immature DCs (iDCs) express high levels of Fpr2 with down-regulation of CCR2 after exposure to bacterial PAMPs or environmental stimuli. Fpr2 then mediates DC trafficking to the peribronchiolar regions in response to the endogenous chemotactic ligand CRAMP, which is increased in the inflamed lungs. In the peribronchiolar areas, inflammatory iDCs undergo maturation in association with the expression of high levels of the chemokine GPCR CCR7 for further homing into draining lymph nodes to initiate adaptive immune responses.