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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Cytokine Growth Factor Rev. 2017 Sep 1;38:10–21. doi: 10.1016/j.cytogfr.2017.08.002

Figure 3. Configurational structure of IL-15 superagonist fusion protein.

Figure 3

RLI is a recombinant IL-15 superagonist composed of human IL-15 with the high-affinity IL-15 binding domain (sushi domain) of human IL-15 Rα through a linker, while ALT-803 is constructed by a high-yield recombinant mammalian cell line that co-expresses a human IL-15 mutant (IL-15N72D) and the sushi domain of human IL-15 Rα fused with the Fc domain of IgG1. Additionally, IL-15 superagonist can be generated by coupling IL-15 and IL-15 Rα-IgG1-Fc chimera in solution through a high-affinity non-covalent association.