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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Cytokine Growth Factor Rev. 2017 Sep 1;38:10–21. doi: 10.1016/j.cytogfr.2017.08.002

Table II.

IL-15/IL-15 Rα-IgG1-Fc.

Research group IL-15 superagonsit Effect on NK cells Effect on CD8+ T cells Improved survival and/or tumor clearance of Anti-tumor effects mediated by
Epardaud et al IL-15/IL-15 Ra- IgG1-Fc ↑number ↑number, IFN granzyme B -γ and Metastatic melanoma and pancreatic tumor Tumor-resident, but neither circulating CD8+ nor NK or NKT cells
Dubois et al IL-15/IL-15 Ra- IgG1-Fc ↑proliferation and killing ↑proliferation, especially memory subset Metastatic melanoma NK cells, but not T or B cells
Rubinstein et al IL-15/IL-15 Ra- IgG1-Fc ↑proliferation ↑proliferation, especially antigenspecific memory subset NA NA
Guo et al IL-15/IL-15 Ra- IgG1-Fc ↑number, CD69, IFN-γ, granzyme B and perforin ↑number, especially memory subset, and granzyme NA NA
Stoklasek et al IL-15/IL-15 Ra- IgG1-Fc ↑proliferation ↑proliferation, especially memory subset; differentiation to effector and long-term memory subsets Metastatic melanoma NA
Huntington et al IL-15/IL-15 Rα- IgG1-Fc ↑reconsitution of human NK cells in humanized mice; CD69, Bcl- 2 and Bcl-xl; ↑reconsitution of human CD8 T cells + in humanized mice NA NA
Wu et al IL-15/IL-15 Ra- IgG1-Fc ↑number and granzyme B ↑number NA NA

FAP: fibroblast activation protein.