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. Author manuscript; available in PMC: 2018 Nov 28.
Published in final edited form as: Circulation. 2017 Oct 4;136(22):2162–2177. doi: 10.1161/CIRCULATIONAHA.117.029557

Figure 5. ERK1/2-MMP-9 signaling is responsible for CTRP9-induced ADSCs proliferation and migration.

Figure 5

A–C. gCTRP9 promoted ADSCs migration (A1, A2, B1, and B2, n=4) and proliferation (C, n=12) were significantly inhibited by pretreatment with U0126 (10μM) or MMP-9 blocking antibody (5μg/mL, 2 hours before gCTRP9 treatment). Data are mean ± SEM. ##P<0.01 vs. DMSO+vehicle; ΦΦP<0.01 vs. DMSO+gCTRP9. D/E. ADSCs apoptosis and death were determined by caspase-3 activity (D, n=4) and LDH release (E, n=12). Data are mean ± SEM. *P<0.05. Statistical significance of C was determined with two-way ANOVA followed by Bonferroni post-hoc test, other data were analyzed with one-way ANOVA followed by Bonferroni post-hoc test.