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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Drug Discov Today. 2017 Aug 3;22(12):1782–1791. doi: 10.1016/j.drudis.2017.07.013

FIGURE 1.

FIGURE 1

Relationship between ribose ring structure and favored conformations as depicted on the pseudorotational cycle, made by a mathematical formula to describe all twists of the ribose ring [5]. P = pseudorotational angle; ν = out of plane angle. On right side: red circle = region of North (N) conformation in nature; with cyan and link circles representing the conformations of the methanocarba rings (left side). Typically: B = nucleobase; Y = H; X = OH. R1 can be oxymethylene or carbonyl moieties.