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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Drug Discov Today. 2017 Aug 3;22(12):1782–1791. doi: 10.1016/j.drudis.2017.07.013

FIGURE 3.

FIGURE 3

X-ray structure of the hP2Y1R showing the binding mode of orthosteric antagonist MRS2500 (3) [38]. In this inactive state, the 3′-phosphate is coordinated by K46 (EL1) and R195 (EL2), the 5′-phosphate deeper in the binding site by T205 (EL2) and R310 (7.39) and N6 by N283 (6.58).