Table 1.
Patient Characteristics
| Characteristic | All patients | Patients with pericardial events | Patients with ischemic events | Patients with arrhythmic events |
|---|---|---|---|---|
| No. | 112 | 9 | 7 | 12 |
| Median age (range, years) | 58 (36–82) | 66 (52–81) | 49 (36–63) | 64 (54–69) |
| Gender | ||||
| Male | 61 (55%) | 3 (33%) | 5 (71%) | 10 (83%) |
| Female | 51 (45%) | 6 (67%) | 2 (29%) | 2 (17%) |
| Tumor laterality | ||||
| Right | 65 (58%) | 8 (89%) | 5 (71%) | 7 (58%) |
| Left | 47 (42%) | 1 (11%) | 2 (29%) | 5 (42%) |
| Stage | ||||
| IIIA | 65 (58%) | 8 (89%) | 5 (71%) | 6 (50%) |
| IIIB | 47 (42%) | 1 (11%) | 2 (29%) | 6 (50%) |
| Histology | ||||
| Adenocarcinoma | 56 (50%) | 4 (44%) | 4 (57%) | 5 (42%) |
| Squamous | 41 (37%) | 5 (56%) | 1 (14%) | 7 (58%) |
| Other | 15 (13%) | 0 (0%) | 2 (29%) | 0 (0%) |
| ECOG Performance status | ||||
| 0 | 73 (65%) | 9 (100%) | 4 (57%) | 10 (83%) |
| 1 | 39 (35%) | 0 (0%) | 3 (43%) | 2 (17%) |
| Baseline WHO/ISH 10-yr risk | ||||
| 0- <10 % | 68 (61%) | 3 (33%) | 5 (71%) | 3 (25%) |
| 10- <20 % | 34 (30%) | 4 (44%) | 2 (29%) | 8 (67%) |
| ≥ 20 % | 10 (9%) | 2 (22%) | 0 (0%) | 1 (8%) |
| Baseline coronary artery disease | ||||
| No | 96 (86%) | 6 (67%) | 5 (71%) | 9 (75%) |
| Yes | 16 (14%) | 3 (33%) | 2 (29%) | 3 (25%) |
| New post-RT pericardial effusion | ||||
| No | 72 (64%) | 0 (0%) | 2 (29%) | 7 (58%) |
| Yes | 40 (36%) | 9 (100%) | 5 (71%) | 5 (42%) |
| Gross tumor volume (median) | 46.6 cc | 48.6 cc | 33.7 cc | 46.4 cc |
| Prescribed RT dose (median) | 74.0 Gy | 74.0 Gy | 74.0 Gy | 74.0 Gy |
Abbreviations: ECOG, Eastern Cooperative Oncology Group; WHO/ISH, World Health Organization / International Society of Hypertension; RT, radiotherapy.