Table 3.
Univariable Competing Risk-Adjusted Analysis for Dosimetric Parameters and Cardiac Events
| Pericardial events | Ischemic events | Arrhythmic events | |||||||
|---|---|---|---|---|---|---|---|---|---|
| P | HR | (95% CI) | P | HR | (95% CI) | P | HR | (95% CI) | |
| Heart | |||||||||
| Mean | 0.016 | 1.04 | (1.01, 1.07) | 0.079 | 1.04 | (0.996, 1.08) | 0.054 | 1.02 | (1.00, 1.05) |
| V5 | 0.042 | 1.02 | (1.001, 1.04) | 0.014 | 1.03 | (1.01, 1.05) | 0.042 | 1.02 | (1.001, 1.04) |
| V30 | 0.024 | 1.02 | (1.003, 1.04) | 0.048 | 1.03 | (1.00, 1.05) | 0.051 | 1.02 | (1.00, 1.03) |
| V60 | 0.004 | 1.04 | (1.01, 1.07) | 0.48 | 0.97 | (0.90, 1.05) | 0.11 | 1.02 | (0.996, 1.04) |
| Left ventricle | |||||||||
| Mean | 0.38 | 1.01 | (0.98, 1.05) | 0.014 | 1.05 | (1.01, 1.09) | 0.80 | 1.0 | (0.97, 1.04) |
| V5 | 0.14 | 1.01 | (0.996, 1.03) | 0.008 | 1.03 | (1.01, 1.05) | 0.24 | 1.01 | (0.99, 1.02) |
| V30 | 0.66 | 1.0 | (0.99, 1.02) | 0.012 | 1.03 | (1.01, 1.05) | 0.71 | 1.0 | (0.98, 1.03) |
| V60 | 0.66 | 1.01 | (0.97, 1.05) | 0.72 | 1.01 | (0.96, 1.06) | 0.17 | 0.93 | (0.85, 1.03) |
| Right atrium | |||||||||
| Mean | 0.009 | 1.03 | (1.01, 1.06) | 0.95 | 1.0 | (0.97, 1.03) | 0.057 | 1.02 | (0.999, 1.05) |
| V5 | 0.044 | 1.02 | (1.001, 1.04) | 0.54 | 1.01 | (0.98, 1.03) | 0.092 | 1.01 | (0.998, 1.03) |
| V30 | 0.013 | 1.02 | (1.004, 1.04) | 0.59 | 1.01 | (0.99, 1.03) | 0.082 | 1.01 | (0.998, 1.03) |
| V60 | 0.005 | 1.02 | (1.007, 1.04) | 0.28 | 0.98 | (0.93, 1.02) | 0.047 | 1.02 | (1.00, 1.03) |
| Left atrium | |||||||||
| Mean | 0.002 | 1.04 | (1.02, 1.07) | 0.32 | 1.02 | (0.98, 1.05) | 0.12 | 1.01 | (0.996, 1.03) |
| V5 | 0.032 | 1.05 | (1.004, 1.10) | 0.14 | 1.02 | (0.99, 1.06) | 0.072 | 1.03 | (0.998, 1.06) |
| V30 | 0.001 | 1.03 | (1.01, 1.05) | 0.29 | 1.01 | (0.99, 1.04) | 0.076 | 1.01 | (0.999, 1.03) |
| V60 | 0.009 | 1.03 | (1.01, 1.05) | 0.82 | 1.0 | (0.97, 1.04) | 0.43 | 1.02 | (0.99, 1.02) |
Abbreviations: HR, subdistribution hazard ratio; V5, volume receiving ≥5 Gy; V30, volume receiving ≥30 Gy; V60, volume receiving ≥60 Gy. Note: For mean dose, all HR’s are per Gy. For V5, V30, and V60, all HR’s are per %.