Table 4.
Characteristic | Univariable Analysis | Multivariable Analysis | ||
---|---|---|---|---|
P | HR (95% CI) | P | HR (95% CI) | |
Age (years) | 0.95 | 1.00 (0.98, 1.02) | ||
ECOG PS (1 vs. 0) | 0.044 | 1.52 (1.01, 2.29) | 0.09 | 1.45 (0.94, 2.24) |
Gross tumor volume (cc) | 0.086 | 1.00 (1.00, 1.004) | ||
WHO/ISH 10-yr risk (stratum) | 0.73 | 0.96 (0.76, 1.21) | ||
Baseline CAD | 0.83 | 0.94 (0.54, 1.63) | ||
Esophagus mean dose (Gy) | <0.001 | 1.04 (1.02, 1.07) | 0.08 | 1.02 (0.997, 1.05) |
Lung mean dose (Gy) | 0.63 | 1.01 (0.96, 1.06) | ||
Heart mean dose (Gy) | 0.18 | 1.01 (0.995, 1.03) | ||
Disease progression* | <0.001 | 7.96 (5.13, 12.35) | <0.001 | 7.48 (4.80, 11.66) |
Symptomatic cardiac event* | 0.008 | 2.09 (1.21, 3.60) | 0.63 | 1.16 (0.63, 2.13) |
Abbreviations: HR, hazard ratio for death; CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status; WHO/ISH, World Health Organization / International Society of Hypertension; CAD, coronary artery disease.
Time-dependent covariate