. Author manuscript; available in PMC: 2018 Nov 1.

Published in final edited form as: Radiother Oncol. 2017 Oct 16;125(2):293–300. doi: 10.1016/j.radonc.2017.10.001

Table 4.

Overall Survival Analysis

Characteristic	Univariable Analysis		Multivariable Analysis
Characteristic	P	HR (95% CI)	P	HR (95% CI)
Age (years)	0.95	1.00 (0.98, 1.02)
ECOG PS (1 vs. 0)	0.044	1.52 (1.01, 2.29)	0.09	1.45 (0.94, 2.24)
Gross tumor volume (cc)	0.086	1.00 (1.00, 1.004)
WHO/ISH 10-yr risk (stratum)	0.73	0.96 (0.76, 1.21)
Baseline CAD	0.83	0.94 (0.54, 1.63)
Esophagus mean dose (Gy)	<0.001	1.04 (1.02, 1.07)	0.08	1.02 (0.997, 1.05)
Lung mean dose (Gy)	0.63	1.01 (0.96, 1.06)
Heart mean dose (Gy)	0.18	1.01 (0.995, 1.03)
Disease progression^*	<0.001	7.96 (5.13, 12.35)	<0.001	7.48 (4.80, 11.66)
Symptomatic cardiac event^*	0.008	2.09 (1.21, 3.60)	0.63	1.16 (0.63, 2.13)

Abbreviations: HR, hazard ratio for death; CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status; WHO/ISH, World Health Organization / International Society of Hypertension; CAD, coronary artery disease.

Time-dependent covariate