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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: J Autoimmun. 2017 Jul 1;85:20–31. doi: 10.1016/j.jaut.2017.06.006

Figure 3.

Figure 3

PI3K is rapidly activated upon the engagement of different cytokine receptors. AKT is a PI3K substrate which, in turn, activates the mTOR complexes thereby regulating numerous cellular functions such as metabolism, protein synthesis, cell growth, proliferation, and survival as well as cytoskeletal rearrangement.