Table 1.
Genotype frequencies of the TAAR1 variants p.Arg23Cys and p.Ser49Leu of diabetes-free individuals from the population-based SHIP-cohort.
| p.Ser49Leu (S49L, rs140960896) | p.Arg23Cys (R23C, rs8192618) | |||||
|---|---|---|---|---|---|---|
| Age group (years) [n] | Non-carriers [n] | Heterozygote A alleles [n] | MAF (%) | Non-carriers [n] | Heterozygote A alleles [n] | MAF (%) |
| 20–29 | 889 | 2 | 0.11% | 890 | 1 | 0.06% |
| 30–39 | 1,356 | 6 | 0.22% | 1,361 | 1 | 0.04% |
| 40–49 | 1,457 | 3 | 0.10% | 1,459 | 1 | 0.03% |
| 50–59 | 1,447 | 7 | 0.24% | 1,453 | 1 | 0.03% |
| Total (younger) | 5,149 | 18 | 0.17% | 5,163 | 4 | 0.04% |
| 60–69 | 1,207 | 5 | 0.21% | 1,212 | 0 | 0.00% |
| 70–79 | 738 | 4 | 0.27% | 742 | 0 | 0.00% |
| 80–83 | 64 | 0 | 0.00% | 64 | 0 | 0.00% |
| Total (older) | 2,009 | 9 | 0.22% | 2,018 | 0 | 0.00% |
| Overall | 7,158 | 27 | 0.19% | 7,181 | 4 | 0.03% |
The genotype frequencies of the single nucleotide variants p.Arg23Cys (R23C, rs8192618) and p.Ser49Leu (S49L, rs140960896) are shown for 5,167 diabetes-free SHIP and SHIP-TREND participants aged younger than 60 years of age (upper part) and 2,018 individuals aged 60 years and older (lower part). MAF, minor allele frequency.