Table 1.
Monte Carlo Simulations (SNR=25 of Fig. 1) | ||||||
---|---|---|---|---|---|---|
Fibril Fraction | 4% | 7% | 10% | 13% | 16% | 20% |
DT (MD mean±std) | 2.23±0.17 | 2.01±0.17 | 1.83±0.16 | 1.68±0.16 | 1.57±0.16 | 1.46±0.16 |
ZP (MD mean±std) | 2.22±0.11 | 2.00±0.10 | 1.82±0.10 | 1.67±0.10 | 1.56±0.10 | 1.45±0.09 |
MD ground truth | 2.22 | 2.00 | 1.82 | 1.68 | 1.56 | 1.45 |
DT (FA mean) | 0.23±0.07 | 0.30±0.07 | 0.36±0.08 | 0.45±0.08 | 0.51±0.08 | 0.59±0.08 |
ZP (FA mean) | 0.19±0.06 | 0.27±0.07 | 0.34±0.07 | 0.44±0.07 | 0.50±0.07 | 0.58±0.07 |
FA ground truth | 0.11 | 0.21 | 0.31 | 0.40 | 0.48 | 0.55 |
DT-synthesised (SNR=25 of Fig. 2) | ||||||
---|---|---|---|---|---|---|
Diffusion Profile [λ1, λ2, λ3] | [2.0 2.0 2.0] | [2.0 2.0 1.4] | [2.0 2.0 0.8] | [2.0 1.4 1.4] | [2.0 1.4 0.8] | [2.0 0.8 0.8] |
DT (MD mean±std) | 2.00±0.17 | 1.80±16 | 1.60±0.16 | 1.60±0.16 | 1.40±0.16 | 1.20±0.16 |
ZP (MD mean±std) | 2.00±0.10 | 1.80±0.09 | 1.59±0.09 | 1.60±0.09 | 1.40±0.08 | 1.20±0.08 |
MD ground truth | 2.00 | 1.80 | 1.60 | 1.60 | 1.40 | 1.20 |
DT (FA mean±std) | 0.21±0.07 | 0.29±0.08 | 0.46±0.08 | 0.31±0.09 | 0.46±0.09 | 0.57±0.11 |
ZP (FA mean±std) | 0.18±0.06 | 0.25±0.08 | 0.40±0.09 | 0.28±0.09 | 0.42±0.10 | 0.54±0.10 |
FA ground truth | 0.00 | 0.19 | 0.41 | 0.21 | 0.40 | 0.52 |
In Vivo (from Fig. 3) | |||
---|---|---|---|
Subjects | Healthy | Patient KL1 | Patient KL2 |
DT (MD mean±std) | 1.62±0.08 | 1.72±0.10 | 1.72±0.09 |
ZP (MD mean±std) | 1.62±0.08 | 1.72±0.10 | 1.72±0.09 |
DT (FA mean±std) | 0.37±0.04 | 0.36±0.05 | 0.33±0.05 |
ZP (FA mean±std) | 0.33±0.05 | 0.32±0.06 | 0.29±0.05 |
All diffusivity (MD and λ’s ) units are in μm2/ms.