Table 1.
Affected protein | EBV-associated pathology | Affected innate lymphocytes | Reference |
---|---|---|---|
Cytotoxic machinery | |||
Perforin | CAEBV, HLH | NK, NKT, γδT | (46) |
Munc13-4 | CAEBV, HLH | NK, NKT, γδT | (47) |
Munc18-2 | CAEBV, HLH | NK, NKT, γδT | (48) |
DNA-binding proteins | |||
GATA2 | CAEBV, HLH | NK | (18, 45) |
MCM4 | EBV lymphoma | NK | (75, 76) |
NF-κB1 | EBV lymphoma | NK | (73, 74) |
Costimulatory receptors and their ligands | |||
CD27 | EBV lymphoma | NKT | (66–68) |
CD70 | EBV-positive Hodgkin’s lymphoma | NKT | (64, 65) |
CD16 | EBV-positive Castleman’s disease | NK | (77, 78) |
NKG2D and TCR (because of MagT1 deficiency) | EBV lymphoma | NK, γδT | (69–72) |
Signaling molecules | |||
SAP | EBV lymphoma, IM, HLH | NKT | (49–51, 54, 55) |
ITK | EBV lymphoma | NKT | (56–63) |
RasGRP1 | EBV lymphoma | NKT | (79) |
PI3K 110δ | EBV viremia | NK | (82) |
Others | |||
XIAP | IM, HLH | NKT | (52, 53) |
Coronin 1A | EBV lymphoma | NKT | (80) |
CTP synthase 1 | IM, EBV lymphoma | NKT | (81) |
CAEBV, chronic active EBV; HLH, hemophagocytic lymphohistiocytosis; IM, infectious mononucleosis; NK, natural killer; EBV, Epstein–Barr virus; NKT, natural killer T; SAP, SLAM-associated protein; XIAP, X-linked inhibitor of apoptosis; ITK, inducible T cell kinase; MCM4, minichromosome maintenance complex component 4; PI3K, phosphatidylinositol-3-kinase.