Table 1.
Sodium hydrosulfide (NaHS) effects on N-methyl-D-aspartate (NMDA) evoked currents in GluN1/2A and GluN1/2B receptors expressed in HEK293T cells.
| Amplitude, nA | Total charge transfer, nC | Iss/Ipk ratio | Desensitization time, s | Deactivation time, s | |
|---|---|---|---|---|---|
| GluN1/2A NMDA receptors | |||||
| Control | 0.40 ± 0.06 | 1.56 ± 0.2 | 0.81 ± 0.02 | 1.3 ± 0.1 | 0.32 ± 0.05 |
| (n = 28) | (n = 28) | (n = 17) | (n = 17) | (n = 17) | |
| NaHS | 0.52 ± 0.09* | 1.83 ± 0.2* | 0.66 ± 0.04* | 0.8 ± 0.07* | 0.45 ± 0.05* |
| Washout | 0.36 ± 0.07 | 1.44 ± 0.2 | 0.86 ± 0.08 | 1.2 ± 0.1 | 0.39 ± 0.11 |
| GluN1/2B NMDA receptors | |||||
| Control | 0.08 ± 0.009 | 0.38 ± 0.05 | 0.91 ± 0.01 | 1.8 ± 0.2 | 0.43 ± 0.05 |
| (n = 48) | (n = 48) | (n = 48) | (n = 18) | (n = 18) | |
| NaHS | 0.06 ± 0.005* | 0.26 ± 0.04* | 0.89 ± 0.01 | 1.6 ± 0.2 | 0.54 ± 0.04* |
| Washout | 0.07 ± 0.01 | 0.32 ± 0.05 | 0.92 ± 0.3 | 1.7 ± 0.4 | 0.46 ± 0.06 |
*p < 0.05 compared to control (paired W-test).