Table 2.
The role of reduction of disulfide bonds in the effects of NaHS on GluN1/2A and GluN1/2B NMDA receptors.
| Amplitude, nA | Total charge transfer, nC | Iss/Ipk ratio | Desensitization time, s | Deactivation time, s | |
|---|---|---|---|---|---|
| GluN1/2A NMDA receptors | |||||
| Control | 0.29 ± 0.09 | 1.1 ± 0.5 | 0.78 ± 0.02 | 1.2 ± 0.1 | 0.32 ± 0.05 |
| (n = 8) | (n = 8) | (n = 8) | (n = 8) | (n = 8) | |
| DTT | 0.42 ± 0.13* | 2.6 ± 1.6* | 0.65 ± 0.07* | 0.6 ± 0.1* | 0.55 ± 0.08* |
| DTT+NaHS | 0.36 ± 0.12 | 2.0 ± 0.6 | 0.66 ± 0.09 | 1.1 ± 0.1 | 0.61 ± 0.11 |
| GluN1/2B NMDA receptors | |||||
| Control | 0.11 ± 0.02 | 0.45 ± 0.1 | 0.91 ± 0.08 | 1.7 ± 0.3 | 0.43 ± 0.05 |
| (n = 8) | (n = 8) | (n = 8) | (n = 10) | (n = 8) | |
| DTT | 0.15 ± 0.01* | 0.58 ± 0.11* | 0.93 ± 0.01 | 1.6 ± 0.2 | 0.78 ± 0.08* |
| DTT+NaHS | 0.11 ± 0.02# | 0.44 ± 0.1# | 0.92 ± 0.03 | 1.5 ± 0.2 | 0.82 ± 0.1 |
*p < 0.05 compared to control; #p < 0.05 compared to dithiothreitol (DTT; paired W-test).