FIGURE 4.

Taxonomic relationships of Actinobacteria with PTM BGCs. The phylogeny was reconstructed using rpoB, and Micrococcus luteus was used as root. Posterior probability values are shown at the nodes. Organisms closely related to Streptomyces albus are highlighted in blue, including our Conus-associated strains (shown in bold letters). If reported, association with eukaryotic hosts is indicated with colored circles. The bars at the right represent the genome length for each taxon; a red line indicates the average genome length for Streptomyces species; and the flanking gray lines show its standard deviation. Accordingly, genomes smaller than 7.2 Mbp as those from insect-, sponge- and cone snail-associated streptomycetes are considered significantly reduced and genetically related.