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. 2017 Nov 28;7:16469. doi: 10.1038/s41598-017-16714-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Yap-Egfr-Erk axis in the resealing epithelial cells. (A) A schematic view of the Yap-Egfr-Erk signalling pathway and Gefitinib, an Egfr inhibitor. (B) A representative image of the FRET/CFP ratio of the resealing epithelial cells before (0 min) and after (20 min) Gefitinib treatment. The lower and upper limits of the FRET/CFP range are expressed with an IMD colour bar. Scale bar, 50 μm. (C) Three independent experiments were performed, and 13–15 cells were analysed in each experiment. The FRET/CFP ratio of individual cells at 20 min after treatment with solvent (denoted as a negative control) or Gefinitib was normalized to the FRET/CFP ratio before treatment (p < 0.0001, unpaired t-test). (D) The immunohistochemical images of Yap and Cdh1 in the normal ileum (upper panels) and 48 h after the ischemia (lower panels). Arrows indicate cells with Yap nuclear translocation. The images are representative of the 3 independent experiments. Bar, 100 μm.