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. 2017 Nov 28;11(6):531–542. doi: 10.1111/irv.12513

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© 2017 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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EpiCC score comparisons between hemagglutinin (HA) sequences of FluSure vaccine (FS) viruses and field viruses. Each axis corresponds to the HA sequence of 1 virus. EpiCC score = Scores of shared epitopes ‐ Scores of strain‐ and vaccine‐unique epitopes. HA sequences in the same cluster had the highest EpiCC scores. For each vaccine virus, class I and II EpiCC scores were significantly different from each other (P < .05). Note that for comparisons where the score for unique epitopes was greater than the score for shared epitopes, EpiCC scores were below zero