Figure 5.

Definition of threshold for prediction of vaccine efficacy prediction. Total EpiCC scores (sum of class I and II EpiCC scores; blue line) for the comparison of H1γ FS and each viral strain are shown. The FS γ‐cluster vaccine strain was protective or partially protective against challenge with viruses annotated as (P) or (PP), respectively. The rest of the viruses were not tested as challenge strains. Protection and partial protection thresholds (black lines) defined 3 areas shown in white (protection; total EpiCC score above −0.001), light gray (partial protection), and dark gray (no protection). Viruses used to set the thresholds are marked with an asterisk (*). We hypothesize that FS would confer at least partial protection against challenge with viruses that had EpiCC scores outside the darker gray region