Table 2.
MDT‐637 IC50s within various laboratory and clinical Respiratory syncytial virus (RSV) strains representing broad genotypic diversity
| RSV genotype | RSV strain (clade name) | Source | MDT‐637 IC50(ng/mL) | 95% CIa , b |
|---|---|---|---|---|
| A | A Long (NH/A1) | Laboratory | 1.42 | 1.2‐1.68 |
| A2 (NH/A1) | Laboratory | 3.4 | 2.25‐5.13 | |
| Memphis‐37 (NH/A2) | Clinical | 1.4 | 0.98‐1.98 | |
| LAP0824 (NH/A4) | Clinical | 0.36 | 0.30‐0.43 | |
| B | 9320 (NH/B1) | Laboratory | 1.73 | 1.16‐2.58 |
| HAN1135 (NH/B3) | Clinical | 0.61 | 0.35‐1.06 |
a
CI, Confidence Interval.
b
CI is calculated based on the experiments performed in duplicate and with each experiment having two separate qPCR determinations per experiment per drug concentration.