. 2017 Oct 30;11(6):525–530. doi: 10.1111/irv.12503

Table 3.

The ratios of MDT‐637 concentration in respiratory secretion to IC₅₀s

Dosing time point	Concentration of MDT‐637 in respiratory secretion/IC₅₀
	From saline nasal wash, uncorrected for solubility		Using 1/180 aqueous to simulated lung fluid29, 30solubility ratio
	RSV‐Memphis‐37	RSV‐A Long	RSV‐Memphis‐37	RSV‐A Long
0.25 hour peak	34.04‐fold^a	33.56‐fold^a	6128‐fold^a	6041‐fold^a
6 hour trough	8.34‐fold^a	8.23‐fold^a	1502‐fold^a	1481‐fold^a

Mean of achievable nasal wash concentrations is from phase I clinical trial data of 66 μg aerosol TID and 132 μg aerosol TID. Peak and trough concentrations from the both dosing groups were measured pre‐dosing and 15 minutes post‐aerosol dosing on the 6th day of treatment and then averaged the values.