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. 2017 Nov 28;7:16495. doi: 10.1038/s41598-017-16472-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Survival curves of 5 overlapped genes between the experimentally validated genes and the Oncomine data. (a) Kaplan-Meier survival curves of HIST1H2BD, HIST1H4K, HIST1H2BH, HIST1H2BJ and HIST1H2AM were used to explore the relationship between the expression of genes and the survival rate. The expression of HIST1H2BD and HIST1H2BJ was significantly correlated with the survival rate of cervical squamous cell cancer patients, with a p-value equaling 0.02318 and 0.03417, respectively. The expression of the other 3 genes was not significantly correlated with the survival rate. Survival analyses of two gene sets (HIST1H2BD and HIST1H2BJ; and HIST1H2BD, HIST1H4K, HIST1H2BH, HIST1H2BJ and HIST1H2AM) demonstrated that both gene sets were related to survival (p = 0.04789 and 0.00850, respectively). (b) Protein-PPI network analysis of histone genes enriched in the SLE pathway. HIST1H2BD, which acted as a seed gene, is marked in yellow. Nodes denote proteins, and edges denote interactions. The width of each line represents the combined-score of interaction between two nodes (the score is also marked on each edge).