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. 2017 Nov 28;7:16540. doi: 10.1038/s41598-017-16418-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlations between species richness and Shannon diversity index within subgroups. In the B+C+ subgroup, the coefficient is as high as 0.7 for the Normal group, whereas it declines to 0.37 and 0.48 for patients with epithelial precursor lesions and OSCC, respectively. The B−C+ subgroup shows a similar pattern. In the B* C* subgroup, the coefficients are 0.42 for the Normal group and 0.7 for the other subgroups. In the B−C* subgroup, the correlation between species richness and the Shannon diversity index for the Normal group is very weak.