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. 2017 Nov 28;8:1832. doi: 10.1038/s41467-017-01979-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Nanoscale sensing of myelin swelling under osmotic challenge. a SpeRe on the myelinated axon in the freshly sliced brain cortex under osmotic challenge. The osmotic pressure changed from 240 to 360 mOsm L⁻¹. b Representative reflectance spectra from the demarcated regions in a. Arrows in corresponding colors indicate the peaks. c Quantification of spectral shift in response to changes in osmotic pressure (n = 4 axons)