Table 1.

Pstpip2 mutant mice strains as disease models for CRMO. cmo chronic multifocal osteomyelitis, ENU N-ethyl-N-nitrosourea, Pstpip2 proline-serine-threonine phosphatase-interacting protein 2

Pstpip2 mutant mice	Generation	Mutation	References
lupo mice	ENU mutagenesis, homozygous mutation	p.I282N c.Y180C	[52, 53]
cmo mice	Homozygous spontaneous mutation	p.L98P Exon5: c.T293C	[26, 54, 28, 55, 56]
Targeted knockout	Conventional knockout Conditional knockout	Target exons 3 and 4	[57]