Table 1.
Baseline demographics and clinical characteristics
| Characteristic | Age 18–64 years [n = 54,971] | Age ≥ 65 years [n = 8788] |
p Value |
|---|---|---|---|
| Female | 31,037 (56.5) | 4845 (55.1) | 0.0197 |
| CD | 24,929 (45.3) | 3393 (38.6) | < 0.0001 |
| UC | 30,042 (54.7) | 5395 (61.4) | |
| Time from diagnosis to index, years | |||
| Mean | 1.14 | 1.42 | < 0.0001 |
| Median (SD) | 0.85 (1.1) | 1.10 (1.2) | |
| Region | |||
| Northeast | 10,291 (18.7) | 1895 (21.6) | < 0.0001 |
| Midwest | 13,872 (25.2) | 2734 (31.1) | |
| South | 20,073 (36.5) | 2488 (28.3) | |
| West | 8871 (16.1) | 1587 (18.1) | |
| Unknown | 1864 (3.4) | 84 (1.0) | |
| Type of health insurance | |||
| Comprehensive | 1714 (3.1) | 3798 (43.2) | < 0.0001 |
| HMO | 6062 (11.0) | 966 (11.0) | |
| POS | 3257 (5.9) | 281 (3.2) | |
| PPO | 33,790 (61.5) | 3521 (40.1) | |
| Missing/unknown | 10,148 (18.5) | 222 (2.5) | |
| Index year | |||
| 2010 | 13,449 (24.5) | 2103 (23.9) | 0.0203 |
| 2011 | 13,691 (24.9) | 2141 (24.4) | |
| 2012 | 11,681 (21.2) | 1818 (20.7) | |
| 2013–2014 | 16,150 (29.4) | 2726 (31.0) | |
| Comorbidities | |||
| Anemia | 5907 (10.7) | 1436 (16.3) | < 0.0001 |
| Cancer | 2393 (4.4) | 1450 (16.5) | < 0.0001 |
| COPD | 905 (1.6) | 1005 (11.4) | < 0.0001 |
| Depression | 3687 (6.7) | 493 (5.6) | 0.0001 |
| Diabetes | 3333 (6.1) | 1689 (19.2) | < 0.0001 |
| Hypertension | 9241 (16.8) | 4379 (49.8) | < 0.0001 |
| Ischemic heart disease | 1390 (2.5) | 1655 (18.8) | < 0.0001 |
| Osteoporosis | 885 (1.6) | 531 (6.0) | < 0.0001 |
| Peripheral vascular disease | 254 (0.5) | 453 (5.2) | < 0.0001 |
| Solid organ transplant | 123 (0.2) | 22 (0.3) | 0.6271 |
| Charlson comorbidity index | |||
| Mean score (SD) | 0.29 (0.89) | 1.00 (1.52) | < 0.0001 |
| Score = 0 | 45,590 (82.9) | 4720 (53.7) | |
| Score ≥ 1 | 9381 (17.1) | 4068 (46.3) | |
| Baseline medication | |||
| 5-ASA | 25,481 (46.4) | 4528 (51.5) | < 0.0001 |
| Polypharmacy | |||
| Mean (SD) | 3.0 (2.3) | 4.8 (2.5) | < 0.0001 |
| 0–4 medications | 41,775 (76.0) | 4062 (46.2) | |
| 5 + medications | 13,196 (24.0) | 4726 (53.8) | |
Data are expressed as n (%) unless otherwise specified
5-ASA 5-aminosalicylic acid, CD Crohn’s disease, COPD chronic obstructive pulmonary disease, HMO health maintenance organization, POS point-of-service, PPO preferred provider organization, SD standard deviation, UC ulcerative colitis