Fig. 3.

Knockdown of ΔNp73 decreases doxorubicin efflux and cell proliferation. (a, b) shΔNp73 MDA-MB-231 and siΔNp73 MCF7 cells show increased retention of doxorubicin (DRB) compared to control cells after 30 min DRB incubation followed by 3 h incubation in normal media. (c, d) Significant reduction of cell proliferation in shΔNp73 MDA-MB-231 and MCF7 cells upon doxorubicin treatment as measured by WST-1 activity. All samples were run in triplicate in three independent experiments. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.005 and ****p < 0.001