Table 1.
Anthropometric and biochemical parameters in control, AHB, AHB after treatment and CHB groups.
| Variables | Control (n = 200) | AHB (n = 33) | AHB after treatment (n = 12) | CHB (n = 75) |
|---|---|---|---|---|
| Age (year) | 40.4 ± 9.5 | 44.7 ± 14.9* | 35.9 ± 11.8 | 35.9 ± 11.7*# |
| Male (n, %) | 67 (34%) | 27 (82%) | 8 (67%) | 55 (73%) |
| BMI (kg/m2) | 22.1 ± 2.2 | 22.0 ± 2.2 | 20.2 ± 2.4*,# | 22.3 ± 2.8 |
| AST (U/L)† | 18.0 (16.0, 21.0) | 690.0 (351.5, 845.0)* | 54.0 (26.3, 120.5)*,# | 157.0 (79.0, 315.0)*,# |
| ALT (U/L)† | 14.0 (10.0, 18.0) | 1548.0 (1205.0, 2141.5)* | 299.5 (58.3, 422.8)*,# | 320.0 (161.0, 754.0)*,# |
| GGT (U/L)† | 16.0 (13.0, 20.0) | 175.0 (136.0, 307.5)* | 118.0 (83.0, 224.3)* | 84.0 (50.0, 166.0)*,# |
| ALP (U/L)† | 64.0 (53.0, 76.0) | 144.0 (115.0, 175.0)* | 84.0 (79.0, 111.3)*,# | 86.0 (66.0, 111.0)*,# |
| TBil (μmol/L)† | 11.2 (8.5, 14.6) | 74.4 (36.9, 145.4)* | 21.3 (16.2, 26.4)*,# | 18.5 (13.3, 41.5)*,# |
| TBA (μmol/L)† | 3.3 (2.3, 4.8) | 109.8 (30.8, 212.1)* | 7.7 (4.9, 19.6)*,# | 16.2 (9.1, 53.9)*,# |
| CRP (mg/L)† | 0.4 (0.2, 0.9) | 5.7 (1.9, 15.4)* | / | 2.0 (1.6, 4.4)*,# |
| Cholinesterase (U/L)† | 330.0 (290.3, 370.8) | 255.0 (226.5, 299.5)* | 264.0 (207.8, 316.0)* | 268.0 (186.0, 320.0)* |
| A/G† | 1.88 (1.72, 2.05) | 1.63 (1.51, 1.78)* | 1.81 (1.59, 2.08) | 1.60 (1.40, 1.80)* |
| Albumin (g/L)† | 48.0 (46.0, 49.0) | 41.0 (38.5, 42.5)* | 43.0 (38.5, 45.0)* | 42.0 (38.0, 44.0)* |
| Total protein (g/L)† | 73.0 (70.3, 76.0) | 64.0 (61.0, 68.5)* | 65.0 (62.3, 70.3)* | 67.0 (62.0, 71.0)* |
| TC (mmol/L)† | 4.4 (3.9, 5.0) | 3.5 (3.2, 4.2)* | / | 4.0 (3.7, 4.5)*,# |
| Triglyceride (mmol/L)† | 1.0 (0.7, 1.4) | 1.7 (1.1, 2.4)* | / | 1.1 (0.8, 1.4)# |
| HDL-C (μmol/L)† | 1.4 (1.2, 1.6) | 0.5 (0.3, 0.8)* | / | 1.2 (0.6, 1.4)*,# |
| LDL-C (μmol/L)† | 2.7 (2.3, 3.3) | 1.9 (1.5, 2.5)* | / | 2.2 (1.7, 2.7)* |
| LgHBV-DNA (IU/ml)† | / | 3.7 (1.0, 5.6) | 1.0 (1.0, 2.0)# | 6.8 (5.4, 7.6)# |
| FGF21 (pg/ml)† | 198.4 (152.8, 272.2) | 243.3 (189.6, 451.7)* | 112.8 (83.2, 186.3)*,# | 142.8 (82.0, 265.3)*,# |
*P value < 0.05 vs. control. #P value < 0.05 vs. AHB. †Log-transformed before analysis.
CRP and lipid profiles in the group of AHB after treatment were not measured.
A/G, albumin/globulin; AHB, acute hepatitis B; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CRP, c-reactive protein; CHB, chronic hepatitis B; FGF21, fibroblast growth factor 21; GGT, gamma-glutamyl transpeptidase; HBV, hepatitis B virus; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TBA, total bile acid; TBil, total bilirubin; TC, total Cholesterol.