Table 2.
Variables | CHB (n = 75) | CHB-Cirrhosis (n = 40) | CHB-ACLF (n = 17) | CHB-HCC (n = 9) |
---|---|---|---|---|
Age (year) | 35.9 ± 11.7 | 47.6 ± 15.6* | 41.4 ± 15.0 | 56.7 ± 8.7* |
Male (n, %) | 55 (73%) | 29 (73%) | 12 (71%) | 7 (78%) |
BMI (kg/m2) | 22.3 ± 2.8 | 22.5 ± 2.4 | 23.1 ± 2.7 | 24.1 ± 2.8 |
AST (U/L)† | 157.0 (79.0, 315.0) | 50.5 (38.3, 138.0)* | 405.0 (173.0, 879.0)* | 65.0 (34.5, 117.5)* |
ALT (U/L)† | 320.0 (161.0, 754.0) | 67.5 (33.0, 177.8)* | 692.0 (268.0, 968.5) | 57.0 (37.5, 122.5)* |
GGT (U/L)† | 84.0 (50.0, 166.0) | 48.5 (25.8, 121.5)* | 103.0 (59.5, 139.0) | 147.0 (73.5, 232.5) |
ALP (U/L)† | 86.0 (66.0, 111.0) | 92.0 (76.5, 126.5) | 106.0 (91.5, 151.0)* | 123.0 (92.5, 228.5)* |
TBil (μmol/L)† | 18.5 (13.3, 41.5) | 24.6 (15.1, 48.3) | 197.6 (98.3, 294.2)* | 19.9 (9.7, 79.7) |
TBA (μmol/L)† | 16.2 (9.1, 53.9) | 29.5 (10.8, 64.3) | 169.1 (109.5, 208.2)* | 6.9 (4.0, 86.6) |
CRP (mg/L)† | 2.0 (1.6, 4.4) | 0.7 (0.3, 7.9) | 9.6 (4.9, 16.2)* | 9.7 (2.5, 11.4) |
Cholinesterase (U/L)† | 268.0 (186.0, 320.0) | 164.0 (98.0, 251.5)* | 140.0 (119.5, 173.5)* | 208.0 (112.0, 353.0) |
A/G† | 1.60 (1.40, 1.80) | 1.30 (0.88, 1.50)* | 1.41 (1.12, 1.64)* | 1.74 (1.22, 1.91) |
Albumin (g/L)† | 42.0 (38.0, 44.0) | 35.0 (31.0, 40.3)* | 34.0 (31.5, 38.5)* | 42.0 (31.5, 45.0) |
Total protein (g/L)† | 67.0 (62.0, 71.0) | 67.0 (62.5, 71.0) | 61.0 (58.0, 65.0)* | 66.0 (60.5, 72.5) |
TC (mmol/L)† | 4.0 (3.7, 4.5) | 3.8 (3.2, 4.3) | 2.6 (2.0, 3.3)* | 4.2 (3.6, 5.6) |
Triglyceride (mmol/L)† | 1.1 (0.8, 1.4) | 0.9 (0.8, 1.3) | 1.4 (0.9, 1.9)* | 1.1 (0.7, 1.2) |
HDL-C (μmol/L)† | 1.2 (0.6, 1.4) | 1.3 (1.0, 1.4) | 0.2 (0.1, 0.3)* | 1.1 (0.2, 1.4) |
LDL-C (μmol/L)† | 2.2 (1.7, 2.7) | 2.0 (1.8, 2.2) | 1.2 (0.8, 1.7)* | 3.2 (2.0, 3.5) |
LgHBV-DNA (IU/ml)† | 6.8 (5.4, 7.6) | 4.2 (2.7, 5.7)* | 6.5 (3.8, 7.6) | 3.3 (1.0, 5.6)* |
α-fetoprotein (μg/L)† | 11.6 (5.2, 25.5) | 14.5 (4.2, 46.0) | 37.5 (18.7, 201.3)* | 18.3 (4.8, 105.7) |
FGF21 (pg/ml)† | 142.8 (82.0, 265.3) | 90.2 (74.5, 142.9)* | 407.1 (141.8, 640.0)* | 398.6 (224.0, 827.6)* |
*P value < 0.05 vs. CHB †Log-transformed before analysis.
ACLF, acute-on-chronic liver failure; A/G, albumin/globulin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CRP, c-reactive protein; CHB, chronic hepatitis B; FGF21, fibroblast growth factor 21; GGT, gamma-glutamyl transpeptidase; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TBA, total bile acid; TBil, total bilirubin; TC, total Cholesterol.