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. 2017 Nov 28;7:16482. doi: 10.1038/s41598-017-16312-6

Table 2.

Anthropometric and biochemical parameters among CHB patients and CHB patients with advanced liver diseases.

Variables CHB (n = 75) CHB-Cirrhosis (n = 40) CHB-ACLF (n = 17) CHB-HCC (n = 9)
Age (year) 35.9 ± 11.7 47.6 ± 15.6* 41.4 ± 15.0 56.7 ± 8.7*
Male (n, %) 55 (73%) 29 (73%) 12 (71%) 7 (78%)
BMI (kg/m2) 22.3 ± 2.8 22.5 ± 2.4 23.1 ± 2.7 24.1 ± 2.8
AST (U/L) 157.0 (79.0, 315.0) 50.5 (38.3, 138.0)* 405.0 (173.0, 879.0)* 65.0 (34.5, 117.5)*
ALT (U/L) 320.0 (161.0, 754.0) 67.5 (33.0, 177.8)* 692.0 (268.0, 968.5) 57.0 (37.5, 122.5)*
GGT (U/L) 84.0 (50.0, 166.0) 48.5 (25.8, 121.5)* 103.0 (59.5, 139.0) 147.0 (73.5, 232.5)
ALP (U/L) 86.0 (66.0, 111.0) 92.0 (76.5, 126.5) 106.0 (91.5, 151.0)* 123.0 (92.5, 228.5)*
TBil (μmol/L) 18.5 (13.3, 41.5) 24.6 (15.1, 48.3) 197.6 (98.3, 294.2)* 19.9 (9.7, 79.7)
TBA (μmol/L) 16.2 (9.1, 53.9) 29.5 (10.8, 64.3) 169.1 (109.5, 208.2)* 6.9 (4.0, 86.6)
CRP (mg/L) 2.0 (1.6, 4.4) 0.7 (0.3, 7.9) 9.6 (4.9, 16.2)* 9.7 (2.5, 11.4)
Cholinesterase (U/L) 268.0 (186.0, 320.0) 164.0 (98.0, 251.5)* 140.0 (119.5, 173.5)* 208.0 (112.0, 353.0)
A/G 1.60 (1.40, 1.80) 1.30 (0.88, 1.50)* 1.41 (1.12, 1.64)* 1.74 (1.22, 1.91)
Albumin (g/L) 42.0 (38.0, 44.0) 35.0 (31.0, 40.3)* 34.0 (31.5, 38.5)* 42.0 (31.5, 45.0)
Total protein (g/L) 67.0 (62.0, 71.0) 67.0 (62.5, 71.0) 61.0 (58.0, 65.0)* 66.0 (60.5, 72.5)
TC (mmol/L) 4.0 (3.7, 4.5) 3.8 (3.2, 4.3) 2.6 (2.0, 3.3)* 4.2 (3.6, 5.6)
Triglyceride (mmol/L) 1.1 (0.8, 1.4) 0.9 (0.8, 1.3) 1.4 (0.9, 1.9)* 1.1 (0.7, 1.2)
HDL-C (μmol/L) 1.2 (0.6, 1.4) 1.3 (1.0, 1.4) 0.2 (0.1, 0.3)* 1.1 (0.2, 1.4)
LDL-C (μmol/L) 2.2 (1.7, 2.7) 2.0 (1.8, 2.2) 1.2 (0.8, 1.7)* 3.2 (2.0, 3.5)
LgHBV-DNA (IU/ml) 6.8 (5.4, 7.6) 4.2 (2.7, 5.7)* 6.5 (3.8, 7.6) 3.3 (1.0, 5.6)*
α-fetoprotein (μg/L) 11.6 (5.2, 25.5) 14.5 (4.2, 46.0) 37.5 (18.7, 201.3)* 18.3 (4.8, 105.7)
FGF21 (pg/ml) 142.8 (82.0, 265.3) 90.2 (74.5, 142.9)* 407.1 (141.8, 640.0)* 398.6 (224.0, 827.6)*

*P value < 0.05 vs. CHB Log-transformed before analysis.

ACLF, acute-on-chronic liver failure; A/G, albumin/globulin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CRP, c-reactive protein; CHB, chronic hepatitis B; FGF21, fibroblast growth factor 21; GGT, gamma-glutamyl transpeptidase; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TBA, total bile acid; TBil, total bilirubin; TC, total Cholesterol.