Table 4. Distribution of Apo E alleles and genotypes in IS subtypes.
| Alleles/Genotypes | Controls N (%) | LAA | CE | SVD | OTHER | Undetermined | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | P value OR (95%CI) | N (%) | P value OR (95%CI) | N (%) | P value OR (95%CI) | N (%) | P value OR (95%CI) | N (%) | P value OR (95%CI) | ||
| Alleles | |||||||||||
| ε2 | 88 | 10 | 0.044 | 3 | 0.445 | 40 | 0.945 | 2 | 0.588 | 21 | 0.651 |
| (9.92) | (4.20) | 0.500 (0.254–0.983) | (5.56) | 0.629 (0.192–2.065) | (8.26) | 0.986 (0.666–1.462) | (11.11) | 1.516 (0.336–6.832) | (9.05) | 1.123 (0.679–1.857) | |
| ε3 | 866 | 201 | – | 47 | – | 397 | – | 13 | – | 184 | – |
| (82.78) | (84.45) | 1.000 | (87.04) | 1.000 | (82.02) | 1.000 | (72.22) | 1.000 | (79.31) | 1.000 | |
| ε4 | 74 | 27 | 0.047 | 4 | 0.973 | 47 | 0.109 | 3 | 0.135 | 27 | 0.028 |
| (7.30) | (11.34) | 1.614 (1.007–2.587) | (7.14) | 0.982 (0.344–2.807) | (9.71) | 1.372 (0.932–2.019) | (16.67) | 2.665 (0.738–9.624) | (11.64) | 1.694 (1.059–2.712) | |
| Genotypes | |||||||||||
| ε2/ε2 | 5 | 0 | – | 1 | 0.232 | 2 | 0.841 | 0 | – | 0 | – |
| (0.97) | (0.00) | – | (3.70) | 3.894 (0.420–36.147) | (0.83) | 0.844 (0.161–4.425) | (0.00) | – | (0.00) | – | |
| ε2/ε3 | 70 | 10 | 0.176 | 1 | 0.172 | 33 | 0.848 | 2 | 0.258 | 17 | 0.444 |
| (13.62) | (8.40) | 0.613 (0.302–1.245) | (3.70) | 0.244 (0.032–1.848) | (13.64) | 1.045 (0.664–1.647) | (22.22) | 2.702 (0.482–15.143) | (14.66) | 1.259 (0.698–2.270) | |
| ε2/ε4 | 8 | 0 | – | 0 | – | 3 | 0.796 | 0 | – | 4 | 0.166 |
| (1.56) | (0.00) | – | (0.00) | – | (1.24) | 0.838 (0.219–3.204) | (0.00) | – | (3.45) | 2.392 (0.697–8.210) | |
| ε3/ε3 | 366 | 85 | – | 21 | – | 165 | – | 4 | – | 72 | – |
| (71.21) | (71.43) | 1.000 | (77.78) | 1.000 | (68.18) | 1.000 | (44.44) | 1.000 | (62.07) | 1.000 | |
| ε3/ε4 | 64 | 21 | 0.209 | 4 | 0.914 | 34 | 0.521 | 3 | 0.070 | 23 | 0.033 |
| (12.45) | (17.65) | 1.425 (0.820–2.478) | (14.81) | 1.063 (0.352–3.211) | (14.05) | 1.161 (0.735–1.835) | (33.33) | 4.126 (0.892–19.095) | (19.83) | 1.806 (1.049-3.111) | |
| ε4/ε4 | 1 | 3 | 0.017 | 0 | – | 5 | 0.028 | 0 | – | 0 | - |
| (0.19) | (2.52) | 16.525 (1.657–164.773) | (0.00) | – | (2.07) | 11.298 (1.306–97.72) | (0.00) | – | (0.00) | - | |
| ε4 containing | 73 | 24 | 0.169 | 4 | 0.910 | 42 | 0.277 | 3 | 0.095 | 27 | 0.017 |
| (14.20) | (20.17) | 1.445 (0.855–2.441) | (14.81) | 0.939 (0.312–2.823) | (17.36) | 1.265 (0.828–1.932) | (33.33) | 3.678 (0.797–16.987) | (23.28) | 1.868 (1.120-3.115) | |
Abbreviations: CE, cardio-embolic; LAA, large artery atherosclerosis; SVD, small vessel disease.