Table 6. Multivariable logistic regression analysis for risk factors of ischemic stroke.

Characteristics	Model 1		Model 2		Model 3
	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)
Age	0.070	1.011 (0.999–1.023)	0.064	1.011 (0.999–1.023)	0.009	1.011 (1.003–1.020)
Gender	0.990	0.998 (0.733–1.359)	1.000	0.998 (0.735–1.362)	0.982	0.998 (0.802–1.241)
BMI	0.768	0.992 (0.940–1.047)	0.817	0.994 (0.942–1.049)	0.896	0.997 (0.960–1.036)
Glu	<0.001	1.530 (1.288–1.817)	<0.001	1.525 (1.285–1.811)	<0.001	1.527 (1.353–1.724)
TC	0.012	1.334 (1.066–1.669)	0.011	1.339 (1.071–1.675)	<0.001	1.344 (1.149–1.573)
TG	0.022	1.352 (1.045–1.750)	0.024	1.343 (1.040–1.736)	0.001	1.344 (1.122–1.611)
HDL	<0.001	0.198 (0.133–0.295)	<0.001	0.197 (0.132–0.293)	<0.001	0.198 (0.149–0.262)
LDL	<0.001	1.990 (1.496–2.648)	<0.001	1.995 (1.500–2.654)	<0.001	1.969 (1.613–2.404)
Hypertension	0.009	1.574 (1.123–2.208)	0.009	1.569 (1.120–2.199)	<0.001	1.602 (1.264–2.030)
Diabetes	0.053	1.609 (0.993–2.607)	0.051	1.615 (0.997–2.615)	0.007	1.602 (1.141–2.250)
Dyslipidemia	0.129	0.760 (0.533–1.083)	0.128	0.760 (0.533–1.082)	0.028	0.756 (0.589–0.971)
Cardiopathy	0.023	2.489 (1.131–5.476)	0.022	2.515 (1.144–5.526)	0.001	2.488 (1.429–4.332)
APOE genotype
ε3/ε3	1.000		1.000
ε2/ε2	0.971	0.965 (0.139–6.697)	0.976	0.971 (0.140–6.760)
ε2/ε3	0.400	1.215 (0.772–1.910)	0.396	1.217 (0.774–1.913)
ε2/ε4	0.429	0.626 (0.197–1.995)
ε3/ε4	0.739	1.078 (0.693–1.677)
ε4/ε4	0.518	2.096 (0.222–19.783)
ε4-containing			0.856	1.039 (0.685–1.576)
APOE allele
ε3					1.000
ε2					0.678	1.086 (0.736–1.602)
ε4					0.844	1.039 (0.709–1.523)

Abbreviations: BMI, body mass index; F, female; Glu, glucose; HDL, high-density lipoprotein; LDL, low-density lipoprotein; M, male; TC, total cholesterol; TG, triglyceride; TOAST, Trial of ORG 10172 in Acute Stroke Treatment.

Model 1 includes six different APOE genotype; Model 2 includes ε4-containing gene; Model 3 includes three different APOE alleles.