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. 2017 Dec 5;37(6):BSR20170772. doi: 10.1042/BSR20170772

Figure 5. Involvement of FRα in FA-induced decrease in cell proliferation and invasion.

Figure 5

(A) Knockdown efficiency of FRα in HONE1 cells. Cells were transfected with siFRα or siCon for 36 h, and then treated with or without FA for 20 h, the protein level of FRα was detected by Western blot. (B) Cell count assay and (C) CCK-8 assay showed that transfection with siFRα inhibited the FA-induced decrease in cell proliferation. (D) Cell invasion assay and (E) migration assay showed that transfection with siFRα inhibited the FA-induced decrease in cell invasion and migration. (F) Western blot analysis showed that transfection with siFRα inhibited the FA-induced increase in E-cadherin expression; *P<0.05.