4. Dose volume data for contoured urinary bladder

	FNO		RNO		p-value	FMO		RMO		p-value	FGO		RGO		p-value
	Median	SD	Median	SD		Median	SD	Median	SD		Median	SD	Median	SD
D0.1cc (cGy)	1335	111	770	130	ES	1138	180	870	164	ES	1290	185	792	180	ES
D1cc (cGy)	1164	47	580	44	ES	980	100	610	89	ES	1031	150	645	166	ES
D2cc (cGy)	1077	51	539	41	ES	911	28.6	549	25	ES	921	110	607	125	ES
V20 (%)	93	3.7	80	8.7	ES	79	10.5	70	7	0.001	70	8.8	87	6.7	ES
V50 (%)	34	10	13	6.3	ES	24	5.6	10	2.3	ES	17	4.3	22	6.2	0.03
V85 (%)	11	3.3	0.35	0.09	ES	6	1.4	0.5	0.1	ES	6	1.8	0.6	0.01	ES
V95 (%)	7	1.5	0.12	0.03	ES	4	0.7	0.3	0.09	ES	4	1.2	0.1	0.00	ES
Minimum dose (%)	20	5	14	4.2	ES	16	3.6	13	2.5	0.002	20	5.8	22	6.2	0.275
Maximum dose (%)	198	50	120	47	ES	176	49	139	44	0.012	164	48	173	46	0.53
Median dose (%)	55	3.7	36	2.7	ES	43	4.2	32	8.4	ES	56	10	56	13	1.0
Average dose (%)	63	2.8	39	2.9	ES	50	2.8	35	2.3	ES	62	9.1	61	12	0.76

D_0.1cc (cGy), D_1cc (cGy), D_2cc (cGy) – minimum dose to the most exposed 0.1 cm³, 1 cm³, 2 cm³ volume, V₂₀ (%), V₅₀ (%), V₈₅ (%), V₉₅ (%) – volume receiving 20%, 50%, 85%, 95% of the prescribed dose

FNO – Fletcher style tandem ovoid applicator with no optimization, RNO – ring applicator with no optimization, FMO – Fletcher style tandem ovoid applicator with manual optimization, RMO – ring applicator with manual optimization, FGO – Fletcher style tandem ovoid applicator with graphical optimization, RGO – ring applicator with graphical optimization, p < 0.05 – statistically significant, ES – extremely statistically significant (p < 0.0001), SD – standard deviation