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. 2017 Aug 8;76(11):1924–1930. doi: 10.1136/annrheumdis-2017-211351

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(A) Scatterplot of the BCR repertoire in peripheral blood of 11 at-risk individuals who developed arthritis (at-risk - developed arthritis), 10 at-risk individuals who did not develop arthritis (at-risk - no arthritis developed) and 10 autoantibody negative healthy individuals. Each dot represents one clone. The size of the clones is depicted as percentage of the total BCR_heavy sequences. (B) The absolute number of dominant BCR clones (clonal size ≥0.5% of the total repertoire), (C) the impact of all dominant clones combined and (D) the size of the single most dominant clone, in at-risk individuals who developed arthritis (at-risk arthritis, n=11) versus at-risk individuals who did not develop arthritis yet (at-risk no arthritis, n=10), and healthy individuals (healthy, n=10). Bars show mean and SD, ***p<0.0001, **p<0.001 using one-way ANOVA. ANOVA, analysis of variance; BCR, B-cell receptor.