Figure 5.

Effect of DMB on IHC-induced atherosclerosis. ApoE^−/− mice were exposed to RA, IHC, or IHC plus DMB for 8 weeks. En face lesions were quantified in the aorta, aortic arch, and PAs as described in Materials and Methods. (A) Sudan IV–stained PA of each individual mouse examined. (B) Quantitative analysis. The x-axis shows the different areas of the blood vessels (RA versus IHC versus IHC+DMB). The y-axis depicts % of lesion area; n = 4 for RA, 8 for IHC, and 7 for IHC+DMB. Values are means ± SEM; **P < 0.01, *P < 0.05. DMB treatment partially reduced the size of IHC-enhanced lesions in the PA.