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Systematic evaluation of effects of mutations on MHC-I binding affinity. (A) Effects on MHC-I binding affinity of single amino acid mutations at different positions within an epitope. The binding affinity of mutated epitopes was predicted by the use of netMHC-4.0. (B) The distribution of predicted changes in MHC-I binding affinity caused by single amino acid mutations across CTL epitopes in Gag (~171 to ~209 mutations for each epitope, depending on the length).
