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Shiga toxin uptake and intracellular routing. Shiga toxin may be taken up directly after binding to its glycolipid receptor Gb3. Alternatively, the toxin may be endocytosed within a microvesicle. Either way the toxin will undergo retrograde transport via the Golgi to the endoplasmic reticulum and the ribosomes where it may inhibit protein synthesis or induce ribosomal stress and apoptosis.
