Table 2.
Demographic analysis of cisplatin-induced nephrotoxicity patients stratified by gender.
| Variables | Gender | P value | |
|---|---|---|---|
| Female (n = 1154) | Male (n = 3973) | ||
| Age (years), mean ± SD | 56.31 ± 12.40 | 56.15 ± 12.85 | 0.7026 |
| Age group, n (%) | |||
| 20-45 (years) | 254 (22.01) | 800 (20.14) | 0.0089* |
| 45-55 (years) | 280 (24.26) | 1145 (28.82) | |
| > 55 (years) | 620 (53.73) | 2028 (51.04) | |
| Comorbidities | |||
| Diabetes mellitus | 150 (13.00) | 447 (11.25) | 0.1033 |
| Hypertension | 324 (28.08) | 894 (22.50) | < 0.0001* |
| CCI score | |||
| mean ± SD | 4.05 ± 3.10 | 3.69 ± 3.15 | 0.0008* |
| 0 | 290 (25.13) | 1144 (28.79) | 0.0034* |
| 1-2 | 185 (16.03) | 714 (17.97) | |
| > 2 | 679 (58.84) | 2115 (53.23) | |
| NSAIDs prescriptions (n) | |||
| (mean ± SD) | 32.55 ± 38.67 | 22.74 ± 29.24 | < 0.0001* |
| < 25 | 640 (55.46) | 2810 (70.73) | < 0.0001* |
| ≥ 25 | 514 (44.54) | 1163 (29.27) | |
| Contrast medium | |||
| Yes | 745 (64.56) | 2685 (67.58) | 0.0547 |
| No | 409 (35.44) | 1288 (32.42) | |
| Gentamicin and Amikacin | |||
| Yes | 209 (18.11) | 874 (22.00) | 0.0044* |
| No | 945 (81.89) | 3099 (78.00) | |
| CKD or AKI | |||
| Yes | 451 (39.08) | 1468 (36.95) | 0.1877 |
| No | 703 (60.92) | 2505 (63.05) | |
Abbreviations: AKI = acute kidney injury; CCI = Charlson comorbidity index;
CKD = chronic kidney disease; NSAIDs = nonsteroidal anti-inflammatory drugs; SD = standard deviation.
*P value < 0.05.