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Pharmaceutical CCNB1 inhibition (RO-3306) decreased tumor growth of ccRCC with CKAP4 upregulation. A) Colony formation assay showing significantly decreased anchorage-independent growth of both 786-O and RCC4 ccRCC cells with lentiviral CKAP4 upregulation; B) Xenograft mouse model implanted with 786-O cells were treated with RO-3306 showed significantly decreased tumor growth from the 4th week on (**P < 0.01, n=10).
